We have compared two different laser-induced optical light traps for their utility in moving organelles within living animal cells and walled fungal cells. The first trap employed a continuous wave neodymium-yttrium aluminum garnet laser at a wavelength of 1.06 micron. A second trap was constructed using a titanium-sapphire laser tunable from 700 to 1000 nm. With the latter trap we were able to achieve much stronger traps with less laser power and without damage to either mitochondria or spindles. Chromosomes and (...) nuclei were easily displaced, nucleoli were separated and moved far away from interphase nuclei, and Woronin bodies were removed from septa. In comparison, these manipulations were not possible with the Nd-YAG laser-induced trap. The optical force trap induced by the tunable titanium-sapphire laser should find wide application in experimental cell biology because the wavelength can be selected for maximization of force production and minimization of energy absorption which leads to unwanted cell damage. (shrink)

Recently, a number of philosophers of biology have endorsed views about random drift that, we will argue, rest on an implicit assumption that the meaning of concepts such as drift can be understood through an examination of the mathematical models in which drift appears. They also seem to implicitly assume that ontological questions about the causality of terms appearing in the models can be gleaned from the models alone. We will question these general assumptions by showing how the same equation (...) — the simple 2 = p2 + 2pq + q2 — can be given radically different interpretations, one of which is a physical, causal process and one of which is not. This shows that mathematical models on their own yield neither interpretations nor ontological conclusions. Instead, we argue that these issues can only be resolved by considering the phenomena that the models were originally designed to represent and the phenomena to which the models are currently applied. When one does take those factors into account, starting with the motivation for Sewall Wright’s and R.A. Fisher’s early drift models and ending with contemporary applications, a very different picture of the concept of drift emerges. On this view, drift is a term for a set of physical processes, namely, indiscriminate sampling processes. (shrink)

This book focuses upon the perennial question of the existence and nature of an obligation to obey the law. Leading writers have, at one time or another, emphasized considerations such as gratitude, 'divine ordering, ' prudence, contract, autonomy, and utility in seeking to justify, or to deny any justification for, some sort of obligation to obey the positive law. The book provides relevant selections from a sampling of the historical approaches to legal obligation taken by writers such as Plato, Augustine, (...) Aquinas, Hobbes, Locke, Hume, Rousseau, Thoreau, Bentham, Marx and Engels, and Martin Luther King, Jr. These classical discussions are augmented by critical questions and commentary, by independent discussions of the question of legal obligation by a wide range of contemporary writers, and by relevant judicial cases discussing matters such as conscientious objection and civil disobedience. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Religio-Political Narratives in the United States: From Martin Luther King Jr. to Jeremiah Wright by Angela D. Sims, F. Douglas Powe Jr., Johnny Bernard HillOluwatomisin OredeinReligio-Political Narratives in the United States: From Martin Luther King Jr. to Jeremiah Wright Angela D. Sims, F. Douglas Powe Jr., and Johnny Bernard Hill New York: Palgrave, 2014. 216PP. $90.00In a world where racial identity can serve as a means (...) to power or disempowerment, privilege or disadvantage, Christian prophetic speech can offer a corrective to subjugative realities. In Religio-Political Narratives in the United States: From Martin Luther King Jr. to Jeremiah Wright, Angela Sims, F. Douglas Powe Jr., and Johnny Bernard Hill attend to prophetic speech and its direct impact on the political through examining the politico-spiritual discourse and work of three storied black figureheads with roots in the black church: Martin Luther King Jr., Jeremiah Wright, and Barack Obama.It is not surprising that black ecclesial rhetoric is found within the orations of these prominent leaders, but what this work reveals is the relationship between social location, religious constitution, and political alignment. Black identity connected to the prophetic expressive tradition directly confronts any model of relationality that constructs injurious sociality. The prophetic, expressed through particular bodies, makes impossible the separation of church and state. As black identity was historically discoursed through deformation, devaluation, and dehumanization, black prophetic speech sought religious premise to speak back to and refute these ill-constructed social and political “realities.” Religiosity and sociality are affixed, adjoined in, on, and through the tongues of these three black influential figureheads of justice. The voices of King, Wright, and Obama move discursively between the religious and the political, using prophetic speech toward active political policy and toward recognizing those who are invisible in the United States and in the world. Employing the language and ideology of citizenry and community, their work and words ultimately move to emphasize human interconnectedness.Religio-Political Narratives in the United States reaches far and wide within academic discourse. A seminal work for black church studies, politics courses, ethics studies, courses in racial discourse, and Christian theological studies, it traces how the prophetic-political “verse” of these black leaders speaks back to the sinister forces that directly shape the experiences of many in the United States and the world. Blackness, an “invisibilized” identity, is ironically the space from which visibility and justice can materialize. Black identity, then, is prophetic in itself; it teaches audacious sight and visionary speech. [End Page 207]The brilliance of Religio-Political Narratives in the United States is in its characterization under one of its series headings, “Womanist Thought.” This identification is its most subtle yet forceful claim. Arguably grounded in the prophetic, womanist thought seeks to engage in “speaking back” to modes of oppressive practices within the black community and Christian context as a whole. Strangely, though, black women are absent from the text. Sims, Powe, and Hill honor womanist thought through recognizing its prophetic tone but overlook its advocates. Its womanist commitment is thus only partially seen, and questions emerge, such as: How did black women influence King, Wright, and Obama, and how can this be accounted for? How did black women historically influence other black women across time? Cannot voices such as those of Ida B. Wells and Pauli Murray be connected to the cadence of Loretta Lynch or Michelle Obama?The presence of black women’s voices is especially important in order to grant stability to the narration of political influence in the United States from within the black community. What must be avoided is the potential alignment of some sort of messianic imagery (and imagination) onto black male figures—and further, and arguably most importantly—aligning political and social change primarily with black males. Messianic mediation must be distinguished from prophetic illumination. Religio-Political Narratives in the United States wisely illumines the connections between body and policy; now we are prompted to ask: whose bodies are storied as legendary, influential, and worth giving account of?Oluwatomisin OredeinDuke Divinity SchoolCopyright © 2016 The Society of Christian Ethics... (shrink)

Chauncey Wright (1830–1874) was one of the first American philosophers to explore the implications of Charles Darwin's work in evolutionary biology. Wright became a strong supporter of the idea of natural selection and a strong critic of the anti-selectionist and teleological arguments of St. George Jackson Mivart and Herbert Spencer, and he laid the groundwork for the field that is today called evolutionary epistemology. As the mentor of the original Cambridge "Metaphysical Club" (William James, Charles Sanders Peirce, and (...) Oliver Wendell Holmes, Jr.), Wright was also instrumental in the development of the American school of Pragmatism. Although his analytical brilliance was widely acknowledged, he never became professionally successful, and he died in 1874 in his 45th year. (shrink)

Here, Bob Hale and Crispin Wright assemble the key writings that lead to their distinctive neo-Fregean approach to the philosophy of mathematics. In addition to fourteen previously published papers, the volume features a new paper on the Julius Caesar problem; a substantial new introduction mapping out the program and the contributions made to it by the various papers; a section explaining which issues most require further attention; and bibliographies of references and further useful sources. It will be recognized as (...) the most powerful presentation yet of a neo-Fregean program. (shrink)

This paper presents the data gathering of Matthew Fontine Maury at the U.S. Naval Observatory as pushing an epistemic boundary outside traditional laboratory walls. Maury's use and control of civilian navigators explicates the development of an astronomic epistemology deeply embedded in nineteenth century American society. In conclusion, following the movement of epistemic boundaries is offered as a guide to crucial moments in the development of a multifaceted modernity.

One of the key achievements of critical realism has been to expose the modernist myth of universal reason, which holds that authentic knowledge claims must be objectively ‘pure’, uncontaminated by the subjectivity of local place, specific time and particular culture. Wright aims to address the lack of any substantial and sustained engagement between critical realism and theological critical realism with particular regard to: (a) the distinctive ontological claims of Christianity; (b) their epistemic warrant and intellectual legitimacy; and (c) scrutiny (...) of the primary source of the ontological claims of Christianity, namely the historical figure of Jesus of Nazareth. As such, it functions as a prolegomena to a much needed wider debate, guided by the under-labouring services of critical realism, between Christianity and various other religious and secular worldviews. This important new text will help stimulate a debate that has yet to get out of first gear. This book will appeal to academics, graduate and post-graduate students especially, but also Christian clergy, ministers and informed laity, and members of the general public concerned with the nature of religion and its place in contemporary society. (shrink)

I Two Traditions. Scientific inquiry, seen in a very broad perspective, may be said to present two main aspects. One is the ascertaining and discovery of ...

This paper is a reply to George Boolos's three papers (Boolos (1987a, 1987b, 1990a)) concerned with the status of Hume's Principle. Five independent worries of Boolos concerning the status of Hume's Principle as an analytic truth are identified and discussed. Firstly, the ontogical concern about the commitments of Hume's Principle. Secondly, whether Hume's Principle is in fact consistent and whether the commitment to the universal number by adopting Hume's Principle might be problematic. Also the so-called `surplus content' worry is discussed, (...) which points out that the conceptual resources to grasp Hume's Principle vastly outstrip the conceptual resources employed in arithmetical reasoning. And lastly whether Hume's Principle is in bad company with other unsuccessful implicit definitions. In the last section, an account towards our entitlement to Hume&'s Principle is sketched. (shrink)

Marshall and colleagues (2024) contribute to the literature on autonomy and decision-making capacity by focusing on the case of individuals with opioid use disorder who refuse to remain in the hosp...

One worrying aspect of contemporary Western Society is the increasing prevalence of instances of ‘Science Denial’ in popular culture. Examples include both cases where well-attested scientific hypotheses are rejected and conversely, where scientifically discredited ideas are stubbornly retained. The paper raises the question whether the kind of argument for an anti-realist conception of empirical scientific theory considered in my contribution to the inaugural issue of this journal could in principle provide intellectual succour for these trends. The discussion proceeds through an (...) examination of the role of ‘takings for granted’ in all reflective enquiry to the conclusion that a trusting acceptance of the general credibility of informants is a precondition for the exercise of individual epistemic responsibility, and that in that context an acceptance of at least the empirical adequacy, if not the truth, realistically understood, of the teachings of scientists in general is rationally non-optional. (shrink)

This book addresses a very real gap in existing introductory texts that define, explore, and apply key theoretical concepts within the field of film studies.' Alison L. McKee, Assistant Professor, Department of Television-Radio-Film-Theatre, San Jose State University, USA 'This is the book that film students have long been waiting for: a clear, well-written and accessible introduction to film theory. Lucid theoretical exposition and case study film analysis offer readers the most intelligible summary of theory that I have yet encountered.' Paul (...) Sutton, Head of Media, Culture and Language, Roehampton University Film theory has a reputation for being difficult. It is challenging, it takes time and it can frequently leave students feeling inadequate and frustrated. Furthermore, theory can often seem intimidating and oldfashioned and therefore it can be difficult to appreciate its modern-day relevance. Understanding Film Theory aims to disassociate theory from these negative connotations and bring a fresh, modern and accessible approach to the discipline. Each of the fifteen chapters provides an insight into the main areas of debate by introducing key ideas and thinkers. Taking the application of theory as its central theme, the book incorporates a number of exciting and innovative features: 'Reflect and Respond' sections encourage readers to engage critically with theoretical concepts, while seminal texts are concisely summarized without oversimplifying key points. Throughout the book the authors illustrate why theory is important and demonstrate how it can be applied in a meaningful way, with relevant case studies drawn from both classic and contemporary cinema including: Once Upon a Time in the West (1968), Run Lola Run (1998), Moulin Rouge! (2001), Rabbit-Proof Fence (2002), Old Boy (2003), Brokeback Mountain (2005), Mamma Mia! (2008) and Avatar (2009). Additional case studies address key genres ('swashbucklers' and the film musical), film movements (Dogme 95), individual actors (Christian Bale, Judi Dench and Amitabh Bachchan) and directors (Alfred Hitchcock and Guillermo del Toro). Understanding Film Theory is an accessible and comprehensive introduction to film theory. It is the ideal entry point for any student studying film, using clear definitions and explaining complex ideas succinctly. Christine Etherington-Wright is a Senior Lecturer in Film Studies at University of Portsmouth (UK) where she teaches a course on Film Theory. She is the author of Gender, Professions, Discourse (Palgrave, 2008). Ruth Doughty is a Senior Lecturer in Film Studies at University of Portsmouth (UK). She is one of the co-founding editors of the journal Transnational Cinemas and co-edited Sound and Music in Film and Visual Media (2008). (shrink)

This paper explores the complex relationship between the plant evolutionist G. Ledyard Stebbins and the animal evolutionist Theodosius Dobzhansky. The manner in which the plant evolution was brought into line, synthesized, or rendered consistent with the understanding of animal evolution (and especially insect evolution) is explored, especially as it culminated with the publication of Stebbins's 1950 book Variation and Evolution in Plants. The paper explores the multi-directional traffic of influence between Stebbins and Dobzhansky, but also their social and professional networks (...) that linked plant evolutionists like Stebbins with Edgar Anderson, Carl Epling, and the 'Carnegie team' of Jens Clausen, David Keck, and William Hiesey with collaborators on the animal side like I. Michael Lerner, Sewall Wright and L.C. Dunn and other 'architects' of the synthesis like Ernst Mayr, Julian Huxley and George Gaylord Simpson. The compatibility in training, work styles, methodologies, goals, field sites, levels of analysis, and even choice of organismic systems is explored between Stebbins and Dobzhansky. Finally, the extent to which coevolution between plants and insects is reflected in the relationship is explored, as is the power dynamic in the relationship between two of the most visible figures associated with the evolutionary synthesis. (shrink)

Expressions of the form 'S is aware of the fact that p' are commonplace. This book provides a systematic exploration of the relation between knowledge and factual awareness, arguing that knowledge is but one species of factual awareness and that we can understand the possession of objective reasons, the normativity of knowledge, and the nature of knowledge in terms of factual awareness. In this way, the state of factual awareness is, structurally and substantively, a more basic type of state than (...) knowledge. If correct, this undermines a number of ways in which knowledge has been regarded as ‘first’ in recent epistemology. (shrink)

Charles Griswold has written a comprehensive philosophical study of Smith's moral and political thought. Griswold sets Smith's work in the context of the Enlightenment and relates it to current discussions in moral and political philosophy. Smith's appropriation as well as criticism of ancient philosophy, and his carefully balanced defence of a liberal and humane moral and political outlook, are also explored. This 1999 book is a major philosophical and historical reassessment of a key figure in the Enlightenment that will be (...) of particular interest to philosophers and political and legal theorists, as well as historians of ideas, rhetoric, and political economy. (shrink)

In the crucible of the pandemic, it has never before been clearer that, to ensure the relevance and even the survival of the discipline, nursing must cultivate a radical imagination. In the paper that follows, I trace the imperative for conjuring a radical imagination for nursing. In this fever dream for nursing futures, built on speculative visions of what could be, I draw on anarchist, abolitionist, posthuman, Black feminist, new materialist and other big ideas to plant seeds of generative insurrection (...) and creative resistance. In thinking through a radical imagination, I unpack the significance of reparatory history for nursing, a discipline founded on normative whiteness. From there, I consider what it would take to shift the capitalist frame of healthcare to one of mutual aid, which requires the deep work of abolition. With a radical imagination that breaks down the enclosures that contain us through reparatory history, mutual aid and abolition, kinship becomes urgently possible. (shrink)

We now know of a number of ways of developing real analysis on a basis of abstraction principles and second-order logic. One, outlined by Shapiro in his contribution to this volume, mimics Dedekind in identifying the reals with cuts in the series of rationals under their natural order. The result is an essentially structuralist conception of the reals. An earlier approach, developed by Hale in his "Reals byion" program differs by placing additional emphasis upon what I here term Frege's Constraint, (...) that a satisfactory foundation for any branch of mathematics should somehow so explain its basic concepts that their applications are immediate. This paper is concerned with the meaning of and motivation for this constraint. Structuralism has to represent the application of a mathematical theory as always posterior to the understanding of it, turning upon the appreciation of structural affinities between the structure it concerns and a domain to which it is to be applied. There is, therefore, a case that Frege's Constraint has bite whenever there is a standing body of informal mathematical knowledge grounded in direct reflection upon sample, or schematic, applications of the concepts of the theory in question. It is argued that this condition is satisfied by simple arithmetic and geometry, but that in view of the gap between its basic concepts (of continuity and of the nature of the distinctions among the individual reals) and their empirical applications, it is doubtful that Frege's Constraint should be imposed on a neo-Fregean construction of analysis. (shrink)

Many western industrialized countries are currently suffering from a crisis in health human resources, one that involves a debate over the recruitment and licensing of foreign-trained doctors and nurses. The intense public policy interest in foreign-trained medical personnel, however, is not new. During the 1960s, western countries revised their immigration policies to focus on highly-trained professionals. During the following decade, hundreds of thousands of health care practitioners migrated from poorer jurisdictions to western industrialized countries to solve what were then deemed (...) to be national doctor and nursing 'shortages' in the developed world. Migration plummeted in the 1980s and 1990s only to re-emerge in the last decade as an important debate in global health care policy and ethics. This paper will examine the historical antecedents to this ethical debate. It will trace the early articulation of the idea of a 'brain drain', one that emerged from the loss of NHS doctors to other western jurisdictions in the 1950s and 1960s. Only over time did the discussion turn to the 'manpower' losses of 'third world countries', but the inability to track physician migration, amongst other variables, muted any concerted ethical debate. By contrast, the last decade's literature has witnessed a dramatically different ethical framework, informed by globalization, the rise of South Africa as a source donor country, and the ongoing catastrophe of the AIDS epidemic. Unlike the literature of the early 1970s, recent scholarship has focussed on a new framework of global ethics. (shrink)

Interpreting Figurative Meaning critically evaluates the recent empirical work from psycholinguistics and neuroscience examining the successes and difficulties associated with interpreting figurative language. There is now a huge, often contradictory literature on how people understand figures of speech. Gibbs and Colston argue that there may not be a single theory or model that adequately explains both the processes and products of figurative meaning experience. Experimental research may ultimately be unable to simply adjudicate between current models in psychology, linguistics and philosophy (...) of how figurative meaning is interpreted. Alternatively, the authors advance a broad theoretical framework, motivated by ideas from 'dynamical systems theory', that describes the multiple, interacting influences which shape people's experiences of figurative meaning in discourse. This book details past research and theory, offers a critical assessment of this work and sets the stage for a new vision of figurative experience in human life. (shrink)

The philosophical implication that guides the issue addressed here is the following: how does the principle of the common constitute a frontal apophasis to the principle of property in contemporary democracies? I do not pretend to offer an exhaustive answer to this problem. However, I use the argumentative strategy of dividing this paper into three sections: (i) theoretically investigate the dialectical tension between the principle of the common and the principle of property; (ii) analytically observe the premise that the behavioral (...) practices of exacerbated individualism contribute as an act of aversion to the principle of the common and (iii) dwell on the articulation of the notion of the principle of the common as a factor that is present on the threshold between the philosophical vulgar and philosophical universal. Finally, I form some considerations that problematize the naturalized notion of the principle of property in current democracies, in view of the constituent power that the principle of the common holds in the perspective of achieving the well-being of human agents in contemporary community life. (shrink)

In their article, Navin, Brummett, and Wasserman (2022) advance the idea that there are qualitatively different types of decision-making capacity (DMC) for treatment refusals. Departing from what t...

American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

The study of metaphor is now firmly established as a central topic within cognitive science and the humanities. We marvel at the creative dexterity of gifted speakers and writers for their special talents in both thinking about certain ideas in new ways, and communicating these thoughts in vivid, poetic forms. Yet metaphors may not only be special communicative devices, but a fundamental part of everyday cognition in the form of 'conceptual metaphors'. An enormous body of empirical evidence from cognitive linguistics (...) and related disciplines has emerged detailing how conceptual metaphors underlie significant aspects of language, thought, cultural and expressive action. Despite its influence and popularity, there have been major criticisms of conceptual metaphor. This book offers an evaluation of the arguments and empirical evidence for and against conceptual metaphors, much of which scholars on both sides of the wars fail to properly acknowledge. (shrink)

One legacy of post-Enlightenment dualism in the universe of academic discourse is the presence of two approached to notions of duality championed by two differing camps. One camp might arbitrarily be called debunkers; the other might be labeled rationalists. The strategies of the camps are conditioned by traditional notions of inside and outside. Debunkers consider themselves outsiders, beyond a deceptive show filled with tricky mirrors. Rationalists, by contrast, spend a great deal of time among mirrors, listening to explanations from the (...) overseers, attempting to absorb sideshow language, hoping to provide acceptable analytical accounts. If debunkers are intent on discovering generative and, presumably, hidden ideological inscriptions of a given discourse—its situation on what Amiri Baraka calls the “real side” of economic exchange and world exploitative power—rationalists are concerned to study discursive products, to decode or explain them according to forms and formulas that claim to avoid general views or judgments of ideology. Differentiating the camps also is what might be called a thermal gradient: the heat of the debunker’s passion is palpable. It is unnecessary to command him, in the manner of the invisible man’s tormentor, to “Get hot, boy! Get hot!” Rationalists, by contrast, do not radiate. They appear to have nothing personal at stake and remain coolly instructive and intelligently unflappable in their analyses.This tale of an Enlightenment legacy, as I have told it, contrasts a debunking body and rationalist soul. As I have suggested in my opening sentence, however, what is at issue is not so much two actual and substantially distinctive camps as two metonyms for dual approaches to a common subject—namely, notions of duality. My claim is that the Enlightenment reflexivity of academic discourse, devoted to, say, “the Other” and conceived in dualistic terms of self-and-other, expresses itself as an opposition. Thos whom I have called debunkers gladly accept the Other’s sovereignty as a bodily and aboriginal donnée; rationalists work to discover the dynamics of “othering” engaged in by a self-indulgent Western soul. The difficulty of producing usefully analytical or political results for either camp is occasioned by their joint situation within a post-Enlightenment field. Houston A. Baker, Jr. is the Albert M. Greenfield Professor of Human Relations at the University of Pennsylvania. He is a poet whose recent volume Blues Journeys Home appeared in 1985. He is also the author of a number of studies of Afro-American literature and culture, including the forthcoming Modernism and the Harlem Renaissance. (shrink)

When a belief is self-fulfilling, having it guarantees its truth. When a belief is self-defeating, having it guarantees its falsity. These are the cases of “self-impacting” beliefs to be examined below. Scenarios of self-defeating beliefs can yield apparently dilemmatic situations in which we seem to lack sufficient reason to have any belief whatsoever. Scenarios of self-fulfilling beliefs can yield apparently dilemmatic situations in which we seem to lack reason to have any one belief over another. Both scenarios have been used (...) independently to challenge Evidentialism, on which what we may rationally believe is all and only what fits our current evidence. Here we tie the two scenarios together and explore what a knowledge-sensitive evidentialist approach to one implies for the other. (shrink)